Prenatal Diagnosis and Screening provides an introduction to the concept of prenatal screening and diagnosis of conditions likely to affect the fetus. All aspects of prenatal screening and diagnosis will be covered, starting with maternal conditions that affect the fetus, the 11-13+6 and 20-22 week ultrasound scan, chromosome and non-chromosomal abnormalities, screening for common pregnancy complications, principles of screening using non-invasive tests, invasive and non-invasive prenatal diagnosis techniques, newer methods of genetic diagnosis including arrays, whole genome sequencing, the role of the geneticist, and lab techniques including cytogenetics and PCR for single gene disorders.

After taking this module you should be able to demonstrate a knowledge of:

Prenatal screening and diagnosis including features that are commonly found on ultrasound scan, maternal blood tests and other tests, and the diagnoses that can be made;
	The role of the geneticist and lab techniques used for prenatal diagnosis for chromosome abnormalities and single gene disorders such as haemoglobinopathies;
	The clinical screening and diagnosis work carried out in a fetal medicine unit;
	Provide a basis for understanding the fetal medicine MSc module.
The module consists of lectures, tutorials, and a journal club session where you learn to present your critical appraisal of a research paper. There  may be opportunities to attend Fetal Medicine Unit teaching sessions, and to gain insight into genetic testing through observation at clinical diagnostic laboratories.

Introductory reading:

Right or wrong? Looking through the retrospectoscope to analyse predictions made a decade ago in prenatal diagnosis and fetal surgery - Lyn S. Chitty, Alessandro Ghidini, JanDeprest, Tim Van Mieghem, Brynn Levy, Lisa Hui, Diana W. Bianchi, 2020-12
	In case you missed it: The prenatal diagnosis editors bring you the most significant advances of 2018 - Alessandro Ghidini, Diana W. Bianchi, Brynn Levy, Tim Van Mieghem, Jan Deprest, Lyn S. Chitty, 2019-01
	In case you missed it: the editors bring you the most significant advances of 2015 - Jan Deprest, Alessandro Ghidini, Tim Van Mieghem, Diana W. Bianchi, Brigitte Faas, Lyn S. Chitty, 2016-01