PLANNING REGENERATION PROJECTS|GOVERNANCE ARRANGEMENTS IN REGENERATION PROJECTS|ECONOMICS OF REGEN

This module takes a project-based learning approach and requires students to develop a diagnostic account of the problems of a chosen locality in London and...

Delivering Regeneration Projects II (BPLN0063)

This module takes a project-based learning approach and requires students to develop a diagnostic account of the problems of a chosen locality in London and generate their own proposals for policy or intervention. Working in small teams, students will have to define why the chosen location is ‘in need of regeneration’; identify the key issues underpinning ‘the problems’ of the selected area; propose a vision and/or strategies to tackle the problems; and explain how such vision and strategies will be delivered.

At the end of the module students should have gained an empirically grounded understanding of the scope, limitations and potential of urban regeneration interventions; their insertion in urban governance mechanisms; and the nature and implications of the policy decisions involved in urban regeneration.

Neurodegenerative diseases are a very important cause of morbidity and mortality and with an ageing population they are becoming more prevalent. This module is...

Genes and Neurodegenerative Disease (BIOS0001)

Neurodegenerative diseases are a very important cause of morbidity and mortality and with an ageing population they are becoming more prevalent. This module is designed to equip Biosciences and Natural Sciences students with an in depth understanding of the molecular basis of a variety of important neurodegenerative diseases and how this has contributed to our current understanding of their disease mechanisms.

Lectures begin with coverage of basic and more advanced aspects of molecular genetics and the various model systems used to investigate these diseases. This is followed by a description of common pathways involved from a biochemical and cell biology perspective including the importance of protein aggregation, free radical mechanisms, iron regulation and mitochondrial function and the use of stem cells to study and treat the diseases. Finally more detailed clinical, pathological, genetic and mechanistic issues are covered for a number of diseases including: Parkinson’s disease, Alzheimer’s disease, prion diseases, motor neuron disease, mitochondrial diseases and Huntington’s disease.

In tutorials you will be exposed to a broad spectrum of academic and transferable skills. In the Journal Clubs you will to read, discuss and critically evaluate the latest research findings related to the lectures. These sessions will develop your presentation and discussion skills in a group atmosphere.

Indicative Lecture list (based on 2021/22 syllabus):

Genetics and molecular basis of disease
	Patterns of inheritance
	Diseases to genes
	Mutations: mechanisms and consequences
	Protein aggregation
	Metals and neurodegeneration
	Mitochondria and mitochondrial DNA mutations
	Mitochondrial dysfunction in neurodegenerative diseases
	Mechanisms of neurodegenerative diseases
	Parkinson’s disease
	Alzheimer’s disease and Dementia
	Huntington’s disease
	Motor neuron disease