This module explores the processes and molecular mechanisms that underpin the transformation of cancer cells, tumour invasion and metastasis. The focus is on...

The Immune System, Cancer, and its Treatment (INIM0031)

This module explores the processes and molecular mechanisms that underpin the transformation of cancer cells, tumour invasion and metastasis. The focus is on the role of the immune system in detecting growing tumours, and the importance of immune surveillance in preventing, but also shaping, emerging tumours. As such, an understanding of basic immunology is essential for this course.

Cancer is one of the leading causes of premature deaths in this country. Treatments include surgery, radiotherapy, hormones and various forms of cytotoxic chemotherapy.  Physical and chemical oncogenic agents or carcinogens have a subtle relationship with the immune system, and this will be explored.  You will also receive lectures from clinicians working at UCL and the Royal Free Hospital who are at the forefront of treating cancer patients.

Targeting the immune system to treat cancer has dramatically improved survival in some patients.  You will learn how immunotherapy is being used and developed to attack malignant tumours, giving an insight into cancer therapies of the future.

Useful textbooks: 

Cellular and Molecular Immunology (2021), Chapter 18: 'Tumour Immunology', AK Abbas, AH Lichtman, S Pillai, 10th Edition, Elsevier Saunders.

The Biology of Cancer (2014), Robert Allan Weinberg, 2nd Edition, Garland.

Learning outcomes

Knowledge and understanding of the fundamental biology of cancer
	Knowledge of specific examples of haematological and solid tumours
	Insight into how the immune response targets, suppresses and shapes cancer
	Insight into contemporary approaches to cancer therapy with a focus on novel immunotherapies

The principal aim of this module is to foster an in-depth knowledge, understanding and critical appreciation of some legal and ethical issues affecting...