Summary

This module will provide an introduction to fundamental contemporary molecular laboratory techniques used in cardiovascular research. Students will undertake practical work covering fundamental laboratory skills and more advanced genetic/molecular biology methods such as genetic screening, sequencing methods and molecular cloning. Topics related to practical sessions will also be covered by lectures, exercises, extensive e-learning, workshops and tutorials.

The module is founded on research into the genetic basis of inherited cardiomyopathies and cross-links to taught sessions in the Cardiovascular Science & Disease (CARD0004) and Genetics of Cardiovascular and Related Complex Diseases (GENE0002) modules.

Learning Outcomes and Objectives

Students successfully completing this module should:

Have practised fundamental laboratory methods in a research laboratory, or if laboratory access is restricted, via online methods
	Describe and debate the key laboratory techniques taught in this module, showing good understanding of the theoretical concepts
	Have experienced and be able to use bioinformatic resources tools related to molecular cardiovascular research in the analysis of genetic data
 

Who is this module for?

This is an optional module for MSc Cardiovascular Science students and is open to any UCL MSc/PG Dip student from an allied subject within SLMS.

Teaching and Learning Methods

Learning will be through practical sessions, lectures, computer exercises, e-learning (online resources, videos and simulations of molecular laboratory methods) in addition to tutorials.

Selected Reading List

Human molecular genetics 4. Tom Strachan and Andrew Read. New York; Abingdon: Garland Science 4th ed. 2011

Edwards J, Bartlett JM. Mutation and polymorphism detection: a technical overview. Methods Mol Biol. 2003;226:287-94.

George AL Jr. Use of contemporary genetics in cardiovascular diagnosis. Circulation. 2014;130(22):1971-80.

Pearson H, Stirling D. Cloning and mutagenesis: a technical overview. Methods Mol Biol 2003;226:464-499.