PHYSICS OF THE NANOSCALE | NANOMATERIALS|THERANOSTICS|DIAGNOSTICS|TISSUE ENGINEERING

Small useful and very strange! During this module you will visit the quantum universe, we will see how nanoscale objects can be tuned for highly specific,...

Small useful and very strange! During this module you will visit the quantum universe, we will see how nanoscale objects can be tuned for highly specific, highly sensitive disease targeting. Students will see how such small scale technology offers huge leaps in diagnostics and therapeutics, enabling us to break the boundary from macroscale anatomy to nanoscale biologics. Anatomical imaging is transformed to functional imaging; treatment becomes targeted. Students will receive a background in clinical imaging modalities (MRI, x-ray CT) and cancer therapies (radiotherapy), and the current and future role of nanotechnology in these fields.

The course will give an overview of the basic information required to build up a picture of the physicochemical properties of a potential drug candidate and...

The course will give an overview of the basic information required to build up a picture of the physicochemical properties of a potential drug candidate and how this information is used to (i) make a decision on the likely developability of a compound and (ii) inform and direct likely formulation strategy. Key concepts to be introduced include solubility, partitioning, acid-base chemistry, dissolution behavior and effect of physical form. The use of the data to inform formulation strategy will be achieved with reference to case studies of marketed products and/or generic drug delivery devices.

 List of lectures:

  Introduction to preformulation
 
  Solubility
 
  Dissolution & partitioning
 
  Crystalline materials
 
  Pseudopolymorphs    
 
  Amorphous materials
 
  Salts
 
  Solid amorphous dispersions
 
  Workshop: Problem-based learning on preformulation

MATHEMATICAL MODELS|OXYGEN TRANSPORT AND ANIMAL RESPIRATION|BALANCE OF FORCES AND EXPRESSIO|ELECT