ADVANCED STRUCTURAL ANALYSIS|THEORETICAL AND APPLIED MECHANICS

This module presents and develops advanced structural analysis methods, to resolve problems relating to structures supporting real buildings, formed of several...

This module presents and develops advanced structural analysis methods, to resolve problems relating to structures supporting real buildings, formed of several structural elements with different functions. This will allow the students to develop their proficiency in analysing and solving building design problems from a structural viewpoint. Theoretical procedures will be applied to real cases via use of numerical simulations and lab-based models.

The course will cover early development of the nervous system (including induction and initial patterning of the CNS, neural progenitors, and genetic analysis...

The course will cover early development of the nervous system (including induction and initial patterning of the CNS, neural progenitors, and genetic analysis of laterality in the developing CNS), origin of neural phenotypes (including organizer patterning in the CNS, migration of neurons and motor circuitry in the developing spinal cord and the plasticity of neural circuits), peripheral development (including neurogenesis and neuron-glial switch, and regulation of Schwann cell development and differentiation), and axons, synapses and circuits (including axon guidance in the visual system of Drosophila, axon outgrowth and Ca2+ in growth cones).

The students will become familiar with the cutting-edge research done at UCL into Developmental Neurobiology. They will grasp and understand the knowledge of the research in this field as it progresses. They will learn about the initial patterning of the nervous system, neuronal differentiation and specification, axon guidance mechanisms and the initial formation of synapses during development and the plasticity of neural circuits. The module will be organized roughly in accordance with the ontogeny of development itself.

Indicative lecture titles

Week 1: Early development

Neurogenesis Paula Alexandre Zebrafish
	Laterality in the CNS Steve Wilson Zebrafish
	Neurulation Gabriel Galea Mouse
Week 2: Mid development

Neuronal cell fate & plasticity Richard Poole C.elegans
	Neurogenesis & glia William Richardson Mouse
	Ear sensory system Nicolas Daudet Mouse
Week 3: Late development

Synapse formation Patricia Salinas Mouse
	Schwann cell development Kristjan Jessen Mouse
	Axon guidance Christiana Ruhrburg Mouse
Week 4: The visual system and neural circuits

Neuron-glia interaction Ryan Macdonald Zebrafish
	Neuron-glia interaction Vil Fernandes Drosophila
	Neural circuit & modulation Arantza Barrios C. elegans