This module will focus on the theory and practice of clinical pharmaceutics: it will consider how the properties of a formulation affect its performance in...

This module will focus on the theory and practice of clinical pharmaceutics: it will consider how the properties of a formulation affect its performance in patients, and will use examples and case studies to illustrate the concepts discussed. In the context of developing new medicines and treatments, we will discuss the unmet clinical need and potential clinical use of a medicine.

 List of lectures:

  Introduction clinical pharmaceutics
 
  Pharmaceutical equivalence and bioequivalence
 
  Pharmaceutical quality
 
  Dissolution: influence of excipients and polymorphs
 
  Pharmaceutical manufacturing and production
 
  Oral preparations –impact of approved medicines on formulation science
 
  Oral preparations –recent developments
 
  Oral preparations – oral formulations and the microbiome
 
  Oral preparations – personalised medicines
 
  Fixed-dose combinations
 
  Liposomal formulations
 
  Microspheres/depots and implants
 
  Topical and transdermal delivery
 
  Radiopharmacy and radiopharmaceuticals
 
  Sub-cutaneous administration as an alternative to intravenous administration
 
  Pulmonary delivery

Molecular Pharmacology is designed to provide core material on the structure and function of neurotransmitter and hormone receptors and the quantitative...

IN VITRO EXPERIMENTS|ISOLATED TISSUES|DATA ANALYSIS|DATA PRESENTATION

Module information

This is a largely practical module, which aims to develop experimental skills. A selection of practicals and follow-up sessions designed...

Module information

This is a largely practical module, which aims to develop experimental skills. A selection of practicals and follow-up sessions designed for students taking Pharmacology PHAR0004 provide reinforcement of the material in that module. This module is not capped.

On completion of the module students will be able to

Conduct simple experiments on in vitro preparations and present their findings in a written account,
	Understand the use of animals in medical research from the standpoint of animal welfare and ethics.
	Set-up tissue preparations and use transducers and computers to measure tension or length changes in smooth muscle preparations.
	Understand the experimental conditions required to maintain tissues in vitro and of the requirements to achieve stimulation of nerves using pulse generators.
	Perform dilutions of stock drug solutions and calculate appropriate volumes to add to organ baths to achieve the desired final concentrations.
	Follow experimental protocols accurately to generate reproducible results
	Quantify results and present them clearly in graphical form.
There are no additional costs for this module – you will be provided with a lab coat and all the necessary laboratory equipment and consumables.

Indicative practical list:

Practical 1: Concentration-Response Curves Practical

Practical 2: Drug Antagonism Practical

Practical 3: Daphnia Practical

Practical 4: Tachykinin Practical

Practical 5: Cutaneous Blood Flow Practical

Practical 6: Stimulated Ileum Practical

Practical 7: Calcium Channel Blockers Practical

Follow-up tutorials will be held after each practical as well as on curve-fitting, report writing, literature searching and ethics.