Aims:

The module aims to equip students to be aware of the conceptual foundations of security policy and technology and their role in delivering robust,...

Philosophy, Politics and Economics of Security and Privacy (COMP0063)

Summary

This course provides a molecular overview of normal human development, working systematically through the organ systems and highlighting mechanisms by...

Molecular Biology of Normal Development and Birth Defects (CHLD0070)

Summary

This course provides a molecular overview of normal human development, working systematically through the organ systems and highlighting mechanisms by which congenital malformations arise. Topics covered in earlier years have included: nervous system, spina bifida; endocrine system, pituitary dysplasia and tumours; heart, structural abnormalities; bone, skeletal dysplasia and dysmorphology; eye, retinal degeneration; kidney, cysts and obstruction; adrenals, cortical and medullary defects; and gastrointestinal tract, innervation and Hirschsprung's disease. The aim of this module is to provide you with knowledge of normal embryology and disorders arising from abnormal development.



Leaning Objectives and Outcomes

After taking this module, you will be able to:

Gain specialist knowledge in embryology and developmental biology
 Increase familiarity with key developmental genes and gene-families
 Describe abnormal development in congenital malformations
 Explain the underlying genetic and molecular pathology of isolated malformations and
syndromes

Outline future potential intervention strategies for these malformations
 Appreciate diverse approaches to therapy development
 Stimulate further research into developmental biology and birth defects
Who is this module for?

This is a core module for the MSc Paediatrics and Child Health: Molecular and Genomic Paediatrics pathway.

Any Level 7 students interested in taking this as an optional module, please contact the Module leader.



Teaching and Learning Methods

This module will be delivered by lectures, tutorials and laboratory demonstrations[PE1] [AP2] .



Assessment

This module will be assessed by a 3,000 word essay.



Selected Reading List

Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R. and Francis-West, P.H., 2014. Larsen's human embryology. Elsevier Health Sciences.
 Ferretti, P., Copp, A., Tickle, C. and Moore, G. eds., 2006. Embryos, genes and birth defects. John Wiley & Sons.