Molecular Aspects of Cell and Gene Therapy (CHLD0034)

The aim of this module is to teach students the basic scientific concepts which underlie cell and gene therapy. The module will introduce aspects of genetics, cell biology, virology, and immunology. In particular, it will cover: basic molecular concepts, viral vector technologies, no-viral vector technologies, genome editing, safety issues in cell and gene therapy, new concepts in cell therapy and preclinical applications in cell and gene therapy.

Learning Objectives and Outcomes 

After taking this module, you should be able to:

Gain a critical understanding of the basic scientific concepts underlying cell and gene therapy.
	Understand the design of different vectors and the advantages and disadvantages of non-viral and different viral delivery techniques.
	Identify potential pre-clinical applications and challenges of the different cell and gene therapy approaches.
Who is this module for? 

This is a core module for the MSc Cell and Gene Therapy.

Teaching and Learning Methods 

This module will be delivered mostly as a series of lectures by GOS ICH/UCL staff with some external experts. There will be the opportunity for you to attend additional GOS ICH/UCL research seminars.

You are expected to invest significant time to self-study outside of class meetings.

Assessment 

This module will be assessed by a 1.5 hour unseen exam with multiple choice questions.

Selected Reading List 

Naldini L. Genetic engineering of hematopoiesis: current stage of clinical translation and future perspectives. EMBO Mol Med. 2019;11.

Doetschman T, Georgieva T. Gene Editing With CRISPR/Cas9 RNA-Directed Nuclease. Circ Res. 2017;120:876-94.

Park SE, Georgescu A, Huh D. Organoids-on-a-chip. Science. 2019;364:960-5.

 

 

Digital Humanities|Human Rights|Networks and Communication|Public Policy and Administration|Security Policy|Technology|Technology Management

DIGITAL|TECHNOLOGY|POLICY|INTERNET OF THINGS|CYBER SECURITY|HUMAN RIGHTS|NETWORKS|POLICY MAKI